Comparative Anatomical, Physiological Studies of reproductive neuroendocrinology ~Leading to an evolutionary model
Lab of Biological Signaling, Department of Biological Sciences, Graduate
School of Science, The University of Tokyo, Shinji Kanda
→main page of Lab of Biological Signaling
School of Science is not a place for medical or agricultual application.
As we do not know what will be useful 100 years after, we are trying to
study what may not be useful in the present time. Our absolute mission
is to expand the study field itself.
Our study is not limitted in mammals, but to suspect the prototype, and to find generality in vertebrates, we have been comparing various neuronal systems in various species in comparison of other studies. However, comparison is not the end. Comparison finds some convergence or extraordinary system that only specific animal groups have, which leads us mysteries of long evolutionary history of vertebrates.
Our materials are mainly in neuroendocrine peptidergic neurons because they are small in number, and each groups show significant distribution and projection (see photos above). These features even provide us good models for understanding subfunctionalized gene evolution because some ligand families have the same receptor in coomon while differential localization and projection characterizes their diffirent functions (subfunctionalization).
We are mainly using medaka, but other vertebrates are also used depending on what we want to know. Such as zebrafish, goldfish, blind cave characin, piranha, Xenopus tropicalis/laevis, lung fish, polypterus, etc...
If you are interested in some topic or techniques represented in papers, please contact by e-mail.
Department of Biological Sciences
Graduate School of Science, The University of Tokyo,
7-3-1 Hongo, Bunkyo, Tokyo. 113-0033